Margo is a model and actress, wheelchair user, known for her work in The Rookie, Leverage: Redemption, and American Crime. She has collaborated on ad campaigns with major brands like Target, Zappos Adaptive, and Starbucks. After a car accident in 2010, Gignac experienced a spinal cord injury, which helped shape her passion for advocacy and authentic disability representation across the entertainment industry. She believes disabled creatives belong in every space in front of the camera, behind it, and on the glam teams shaping what we see.

Gignac and her twin sister were born in L.A., raised in Miami. She lives in Brooklyn with her cats, Leroi and Omlette, and her dog, Mouche.